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[27] [105] however, at much higher doses, amphetamine can induce effects that severely impair performance, such as rapid muscle breakdown and elevated body temperature

Generic semaglutide, a glucagon-like peptide-1 receptor agonist (GLP-1RA), has recently become available in Canada after regulatory exclusivity for semaglutide expired in Canada in January 2026years earlier than expected in the US and countries in Europe

Phase 3 trials running to 68 weeks are starting to answer that question, and the TRIUMPH-4 data suggests that weight loss continues modestly between weeks 48 and 68 in many participants